As with all angiotensin II receptor antagonists, irbesartan is adumbrated for the analysis of hypertension. It may aswell adjournment progression of diabetic nephropathy and is aswell adumbrated for the abridgement of renal ache progression in patients with blazon 2 diabetes, hypertension and microalbuminuria (>30 mg/24 hours) or proteinuria (>900 mg/24 hours).
Irbesartan is aswell accessible in a aggregate conception with a low-dose thiazide diuretic, consistently hydrochlorothiazide, to accomplish an accretion antihypertensive effect. Irbesartan/hydrochlorothiazide aggregate affairs are marketed beneath agnate barter names to irbesartan preparations.
Synonym: Avapro; BMS-186295
CAS Number: 138402-11-6
Molecular Weight: 428.53
Molecular Formula: C25H28N6O
Solubility: Soluble in DMSO (>25 mg/ml), ethanol (~0.5 mg/ml), methanol, DMF (~20 mg/ml), and water (<1 mg/ml at 25 °C).
Melting Point: 180-186 °C
Boiling Point: ~648.6 °C at 760 mmHg (Predicted)
Density: ~1.3 g/cm3 (Predicted)
Application: An angiotensin II type 1 (AII1)-receptor antagonist
Storage: Store at -20° C
Irbesartan is a awful almighty and careful adversary of the AT1 (angiotensin II blazon 1) receptor with an IC50 = 1.3 nM. This admixture has no affection for AT2 receptors. Pretreatment with irbesartan decreases angiotensin II-induced apoptosis in rat vascular bland beef beef by blocking angiotensin II internalization in a concentration-dependent manner.