Coenzyme A is an essential, universally distributed, thiol-containing cofactor that works as the aloft acyl accession carrier in all cells. This atom is circuitous in hundreds of reactions and is adapted for the metabolism of fatty acids, carbohydrates, amino acids and ketone bodies.
Coenzyme A is a aloft regulator of action metabolism, although it about is overlooked. Acetyl-CoA in authentic is strategically positioned at the basic of action metabolism. Just like all the anchorage beforehand to Rome, both anabolic and catabolic pathways accumulate at the accession of this babyish molecule, yet acetyl-CoA maintains acclimation by reinforcing the allocation of pyruvate amidst compound and abasement through its cogwheel acclimation of pyruvate dehydrogenase and carboxylase. Traffic advantage aloft this metabolic accord is exerted by acetyl- and added acyl-CoAs through both allosteric and post-translational regulation.
Coenzyme A is aswell the anterior of the phosphopantetheine accession that is added as a prosthetic accession to proteins such as acyl carrier protein and formyltetrahydrofolate dehydrogenase.