Mycophenolic acid Mechanism of action

Mycophenolic acid is a potent, selective, uncompetitive, and capricious inhibitor of inosine monophosphate dehydrogenase (IMPDH), and accordingly inhibits the de novo alleyway of guanosine nucleotide amalgam after assimilation into DNA. Because T- and B-lymphocytes are alarmingly abased for their admeasurement on de novo amalgam of purines, admitting added corpuscle types can growth deliver pathways, mycophenolic acid has almighty cytostatic furnishings on lymphocytes. Mycophenolic acid inhibits proliferative responses of T- and B-lymphocytes to both mitogenic and allospecific stimulation. Addition of guanosine or deoxyguanosine reverses the cytostatic furnishings of mycophenolic acid on lymphocytes.

Mycophenolic acid aswell suppresses antibiotic accumulation by B-lymphocytes. Mycophenolic acid prevents the glycosylation of lymphocyte and monocyte glycoproteins that are complex in intercellular adherence to endothelial beef and may arrest application of leukocytes into sites of deepening and affix rejection.


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