Fenofibrate is a lipid acclimation abettor adumbrated as accessory analysis to diet to abate animated LDL-C, Total-C,Triglycerides and Apo B, and to access HDL-C in developed patients with primary hypercholesterolemia or alloyed dyslipidemia (Fredrickson Types IIa and IIb). Fenofibrate is aswell adumbrated as accessory analysis to diet for analysis of developed patients with hypertriglyceridemia (Fredrickson Types IV and V hyperlipidemia). Fenofibric acid, the alive metabolite of Fenofibrate, produces reductions in absolute cholesterol, LDL cholesterol, apolipoprotein B, absolute triglycerides and triglyceride affluent lipoprotein (VLDL) in advised patients. In addition, analysis with fenofibrate after-effects in increases in top body lipoprotein (HDL) and apoproteins apoAI and apoAII.
Fenofibrate exerts its ameliorative furnishings through activation of peroxisome proliferator activated receptor a (PPARa). This increases lipolysis and abolishment of triglyceride-rich particles from claret by activating lipoprotein lipase and abbreviation assembly of apoprotein C-III. The consistent abatement in triglycerides produces an about-face in the admeasurement and agreement of LDL from small, close particles, to ample afloat particles. These beyond particles accept a greater affection for cholesterol receptors and are catabolized rapidly.