Deflazacort Description


Deflazacort is a type of anesthetic accepted as a corticosteroid. Corticosteroids are hormones produced by itself by the adrenal glands which accept abounding important functions, including ascendancy of anarchic responses.
Clinical studies accept adumbrated that the boilerplate authority arrangement of deflazacort to prednisolone is 0.69–0.89 and 6 mg of deflazacort is agnate to 5 mg of prednisolone. However, the ameliorative dosage arrangement has been appear to ambit from 1:1.2 to 1:1.5 Due to the abbreviate pharmacokinetic half-life of its alive metabolite, pharmacodynamic furnishings of deflazacort are of beneath continuance than those of methylprednisolone and prednisolone.
Deflazacort is a corticosteroid prodrug, whose alive metabolite, 21-desDFZ, acts through the glucocorticoid receptor to apply anti-inflammatory and immunosuppressive effects. The absolute apparatus by which deflazacort exerts its ameliorative furnishings in patients with DMD is unknown.

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