In beastly studies, flutamide demonstrates almighty antiandrogenic effects. It exerts its antiandrogenic activity by inhibiting androgen uptake and/or by inhibiting nuclear bounden of androgen in ambition tissues or both. Prostatic blight is accepted to be androgen-sensitive and responds to analysis that counteracts the effect of androgen and/or removes the antecedent of androgen, e.g. castration. Elevations of claret testosterone and estradiol levels accept been acclaimed afterward flutamide administration.
Flutamide is a nonsteroidal antiandrogen that blocks the activity of both autogenous and exogenous testosterone by bounden to the androgen receptor. In accession Flutamide is a almighty inhibitor of testosterone-stimulated prostatic DNA synthesis. Moreover, it is able of inhibiting prostatic nuclear uptake of androgen.