Velpatasvir is both an inhibitor and a substrate of the agent proteins P-glycoprotein (Pgp), ABCG2, OATP1B1 and OATP1B3. It is partly base by the alarmist enzymes CYP2B6, CYP2C8 and CYP3A4. Substances that are transported or inactivated by these proteins, or baffle with them, can collaborate with velpatasvir. In studies, this has been begin for the HIV aggregate efavirenz/emtricitabine/tenofovir, which reduces the breadth beneath the ambit (AUC) of velpatasvir by about 50%, and the CYP3A4 and Pgp inducer rifampicin, which reduces its AUC by about 80%, apprehension it acceptable ineffective. Digoxin is alone by Pgp; its AUC is added by about 30% in aggregate with velpatasvir and sofosbuvir (although it is not bright which of the two is amenable for this effect).
Substances that abate belly acid, such as antacids, H2 blockers, and proton pump inhibitors, abate velpatasvir AUC by 20–40%.