Chartreusin (CAS 6377-18-0) Description

Synonym: Lambdamycin

Application:      An antiproliferative agent that inhibits topoisomerase II

CAS Number:   6377-18-0

Purity:      ≥98%

Molecular Weight:   640.6

Molecular Formula: C32H32O14

Solubility: Soluble in water (partly miscible), and acetone.

Storage:   Store at 4° C

Density:   1.6 g/cm3 (Predicted)


Chartreusin is a almighty anti-proliferative abettor originally acquired from Streptomyces chartreusis. This admixture has been apparent to be a almighty inhibitor of the catalytic action of Topo II (topoisomerase II). Experiments accept appear that Chartreusin binds to GC-rich tracts in DNA, inhibits RNA synthesis, and causes single-strand scission of DNA via accumulation of chargeless radicals. Additionally, this abettor has been apparent to arrest accumulation of several DNA-protein complexes.


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