Nabumetone Description

Nabumetone is a nonsteroidal anti-inflammatory biologic (NSAID) of the arylalkanoic acerbic ancestors (which includes diclofenac). Marketed beneath the cast name Relafen, it has been apparent to accept a hardly lower accident of gastrointestinal ancillary furnishings than a lot of added non-selective NSAIDs.

Nabumetone is a naphthylalkanone. Is is a non-selective prostaglandin G/H synthase (a.k.a. cyclooxygenase or COX) inhibitor that acts on both prostaglandin G/H synthase 1 and 2 (COX-1 and -2). Prostaglandin G/H synthase catalyzes the about-face of arachidonic acerbic to prostaglandin G2 and prostaglandin G2 to prostaglandin H2. Prostaglandin H2 is the forerunner to a amount of prostaglandins complex in fever, pain, swelling, inflammation, and platelet aggregation. The ancestor admixture is a prodrug that undergoes hepatic biotransformation to the alive compound, 6-methoxy-2-naphthylacetic acerbic (6MNA). The analgesic, antipyretic and anti-inflammatory furnishings of NSAIDs action as a aftereffect of decreased prostaglandin synthesis.


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