Celiprolol Hydrochloride (CAS 57470-78-7) Description

Synonym:   1-{3-acetyl-4-[3-(tert-butylamino)-2-hydroxypropoxy]phenyl}-3,3-diethylurea hydrochloride

CAS Number:      57470-78-7

Molecular Weight:     415.95

Molecular Formula:    C20H33N3O4•HCl

Solubility:      Soluble in Ethanol, Methanol and Water

Storage:   Store at -20° C

Application:     A cardioselective β1-AR inhibitor


Celiprolol Hydrochloride is a cardioselective β1-AR (adrenergic receptor) acquaintance that possesses abeyant antianginal, and antihypertensive properties. Adrenoreceptors, or adrenergic receptors are G protein-coupled proteins complex in a array of affectionate afraid arrangement activities. β1-AR is primarily associated with cardiac achievement effects.


Cumin medicinal uses

In Sanskrit, cumin is accepted as Jira “that which helps digestion”. In the Ayurvedic system, broiled cumin seeds are acclimated for alleviative purposes. These seeds are delicate and acclimated in altered forms like kashaya (decoction), arishta (fermented decoction), vati(tablet/pills), and candy with ghee (a semi-fluid antiseptic butter). It is acclimated internally and sometimes for alien applications, also. It enhances the appetite, aftertaste perception, digestion, vision, strength, and lactation. It is acclimated to in the analysis of fever, accident of appetite, diarrhea, vomiting, belly distension, edema and puerperal disorders.

In southern India, accepted drinks such as Kerala and Tamil Nadu are alleged jira water, which is fabricated by baking cumin seeds. It is believed that cumin is benign for affection disease, swellings, tastelessness, vomiting, poor assimilation and abiding fever.

Ahmad Reza Gohari and Soodabeh Saeidnia accept advised the phytochemistry of Cuminum cyminum seeds and its standards. They accept appear abounding pharmacological furnishings such as anti-diabetic, immunologic, anti-epileptic, anti-tumour and antimicrobial activities.’A abstraction by advisers at Mysore University in India letters the abeyant anti-diabetic backdrop of cumin.

Efraim Lev and Zohar Amar accept appear several alleviative backdrop and bloom allowances of cumin seeds. According to the authors, cumin seeds and balmy jeera baptize is believed to advance saliva beard and to abate digestive disorders.

Methohexital Pharmacology & Indications


Methohexital binds to a audible website which is associated with Cl− ionophores at GABAA receptors. This increases the breadth of time which the Cl− ionopores are open, appropriately causing an inhibitory effect.

Metabolism of methohexital is primarily hepatic via demethylation and oxidation. Side-chain blaze is the primary agency of metabolism complex in the abortion of the drug’s biological activity.

Protein bounden is about 73% for methohexital.


Methohexital is primarily acclimated to abet anesthesia, and is about provided as a sodium alkali (i.e. methohexital sodium). It is alone acclimated in hospital or agnate settings, beneath austere supervision. It has been frequently acclimated to abet abysmal balance or accepted anesthesia for anaplasty and dental procedures. Unlike abounding added barbiturates, Methohexital in fact lowers the access threshold, a acreage that accomplish it decidedly advantageous if anesthesia is provided for a electroconvulsive analysis (ECT). And accelerated accretion amount with alertness getting acquired aural three to seven account afterwards consecration and abounding accretion aural 30 minuntes is a above advantage over added ECT barbiturates (Schulgasser and Borowitz 1963).

Itraconazole use

Itraconazole capsules are acclimated to amusement fungal infections in the lungs that can advance throughout the body. Itraconazole capsules are aswell acclimated to amusement fungal infections of the fingernails. Itraconazole tablets and capsules are acclimated to amusement fungal infections of the toenails. Itraconazole articulate band-aid (liquid) is acclimated to amusement aggrandize infections of the aperture and throat or of the esophagus (tube that connects the throat to the stomach). Itraconazole is in a chic of antifungals alleged triazoles. It works by slowing the advance of fungi that could cause infection.

Itraconazole comes as a capsule, a tablet, and a band-aid (liquid) to yield by mouth. If you are demography itraconazole to amusement fungal infections in the lungs, the capsules are usually taken with a abounding meal one or two times a day for at atomic 3 months. However, if you are demography itraconazole to amusement a austere fungal infection in the lungs, the capsules may be taken with a meal three times a day for the aboriginal 3 canicule of analysis and again taken already or alert a day with a meal for at atomic 3 months. If you are demography itraconazole to amusement fungal infections of the toenails (including or after barb infections), the capsules or tablets are usually taken already a day with a abounding meal for 3 months. If you are demography itraconazole to amusement fungal infections of the fingernails only, the capsules are usually taken alert a day with a abounding meal for 1 week, skipped for 3 weeks, and again taken alert a day with a meal for a week. Itraconazole band-aid is usually taken on an abandoned abdomen already or alert a day for 1 to 4 weeks or sometimes longer. Follow the admonition on your decree characterization carefully, and ask your doctor or pharmacist to explain any allotment you do not understand. Yield itraconazole absolutely as directed. Do not yield added or beneath of it or yield it added generally than assigned by your doctor.