Arctigenin is a accustomed admixture that had never been ahead approved to accept a glucose-lowering effect. Here it was begin to actuate AMP-activated protein kinase (AMPK), and the apparatus by which this occurred, as able-bodied as the furnishings on glucose and lipid metabolism were investigated.
Arctigenin added AMPK phosphorylation and angry glucose uptake in L6 myotubes and abandoned ashen muscles. In primary hepatocytes, it decreased gluconeogenesis and lipid synthesis. The accessory of glucose uptake and abolishment of hepatic gluconeogenesis and lipid amalgam by arctigenin were prevented by barricade of AMPK activation. The respiration of L6 myotubes or abandoned mitochondria was inhibited by arctigenin with a specific aftereffect on respiratory circuitous I. A individual articulate dosage of arctigenin bargain gluconeogenesis in C57BL/6J mice. Chronic articulate administering of arctigenin bargain claret glucose and bigger lipid metabolism in ob/ob mice.